COMBINATION-DRUG THERAPY WITH CALCIUM-CHANNEL BLOCKERS IN THE TREATMENT OF SYSTEMIC HYPERTENSION

Calcium-channel blockers have been shown to be both safe and effective for treatment of patients with systemic hypertension. These drugs red uce peripheral vascular resistance predominantly by the inhibition of transmembrane calcium ion fluxes in vascular smooth muscle, and by thi s mechanism can reduce elevated blood pressure. To maximize blood pres sure lowering efficacy in patients, calcium-channel blockers have also been used in combination with other antihypertensive treatments that have included diuretics, 6-adrenergic blockers, and angiotensin-conver ting enzyme inhibitors.