ISOLATION OF MYCOBACTERIUM-AVIUM COMPLEX FROM BONE-MARROW ASPIRATES OF AIDS PATIENTS IN BRAZIL

Mycobacterium avium complex (MAC) infection has not been reported as a major opportunistic infection among patients with AIDS in Latin Ameri ca or Africa. In this study, 125 AIDS patients who had persistent feve r, anemia, and leukopenia were examined among 2628 AIDS patients admit ted to Instituto de Infectologia Emilio Ribas between May 1990 and Apr il 1992. From the bone marrow aspirates of the 125 patients, MAC was i solated from 23 (18.4%) and Mycobacterium tuberculosis was isolated fr om 9 (7.2%). Between 1985 and 1990, only 11 MAC isolations among 60,00 0 cultures obtained from human immunodeficiency virus-seronegative pat ients were documented in Sao Paulo. Hence, the minimal estimated rate of MAC infection in AIDS patients in this city was 23/2628, or 0.88%. These findings suggest that MAC infection is an important opportunisti c infection, especially among a subset of patients with AIDS in Brazil who have clinical characteristics and risk activities similar to thos e associated with MAC infections in North America and Europe.