REDUCED [H-3] SCH-23390 BINDING AND DA-SENSITIVE ADENYLYL-CYCLASE IN THE LIMBIC SYSTEM OF ETHANOL-PREFERRING RATS

Authors
DEMONTIS MG GAMBARANA C GESSA GL MELONI D TAGLIAMONTE A STEFANINI E
Citation
Mg. Demontis et al., REDUCED [H-3] SCH-23390 BINDING AND DA-SENSITIVE ADENYLYL-CYCLASE IN THE LIMBIC SYSTEM OF ETHANOL-PREFERRING RATS, Alcohol and alcoholism, 28(4), 1993, pp. 397-400
Citations number
15
Categorie Soggetti
Substance Abuse
Journal title
Alcohol and alcoholism → ACNP
ISSN journal
07350414
Volume
28
Issue
4
Year of publication
1993
Pages
397 - 400
Database
ISI
SICI code
0735-0414(1993)28:4<397:R[SBAD>2.0.ZU;2-#
Abstract
Dopamine (DA) D1 receptors and the response of adenylyl cyclase (AC) t o dopamine stimulation were studied in the limbic areas and the caudat e-putamen of Sardinian ethanol-preferring (SP), Sardinian ethanol-non- preferring (SNP) and Wistar unselected (UW) rats. SP rats exhibited a significantly lower number of D1 receptors, measured using [H-3]SCH 23 390 binding, and a decreased response to DA stimulation than SNP and U W animals. Since SP rats have also a low number of D2 receptors, the r esults suggest that an altered dopaminergic transmission may underlie their innate alcohol preference.