A COMPARATIVE-STUDY OF ETHANOL ABSORPTION IN THE CANINE JEJUNUM AFTERPRETREATMENT WITH CYANAMIDE OR PYRAZOLE

This report describes the retardation of ethanol absorption from the i ntestinal tract and reduction of portal blood flow by high acetaldehyd e concentrations in dogs using a jejunal segment with the vascular sup ply intact. The cyanamide-pretreatment group (CY), in which an extreme ly high acetaldehyde concentration developed, in comparison with the c ontrol and pyrazole-pretreated (PY) groups, showed a gradual increase of portal blood ethanol, a 25% reduction in the amount of absorbed eth anol, and an 85% smaller absorption rate constant value (K(a)). These facts indicate that the presence of a high acetaldehyde concentration in the blood results in a reduction of ethanol absorption and retardat ion of ethanol reaching the systemic circulation. The rapid reduction of portal blood flow and the lower ethanol level in the portal vein ob served in the CY group, in comparison with the other two groups, also indicate that the reduction of ethanol permeability through the absorp tion site to the blood is an important retarding factor induced by ace taldehyde.