SYNTHESIS AND HYBRIDIZATION PROPERTIES OF AMIDE-LINKED THYMIDINE DIMERS INCORPORATED INTO OLIGODEOXYNUCLEOTIDES

Authors
IDZIAK I JUST G DAMHA MJ GIANNARIS PA
Citation
I. Idziak et al., SYNTHESIS AND HYBRIDIZATION PROPERTIES OF AMIDE-LINKED THYMIDINE DIMERS INCORPORATED INTO OLIGODEOXYNUCLEOTIDES, Tetrahedron letters, 34(34), 1993, pp. 5417-5420
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
34
Year of publication
1993
Pages
5417 - 5420
Database
ISI
SICI code
0040-4039(1993)34:34<5417:SAHPOA>2.0.ZU;2-I
Abstract
Thymidine dimers, connected by amide or N-methyl amide linkages, have been prepared. The dimers have each been incorporated three times into normal strands of DNA by solid phase synthesis. Thermal denaturation studies indicated that these modifications caused little or no destabi lization of the DNA:RNA duplex.