STUDIES INTO PHARMACOKINETICS OF SULFAMER AZINE IN CALF, FOLLOWING APPLICATION OF PROBENECID

One single dose of 60 mg/kg B. W. of sulfamerazine was intravenously i njected to each of four clinically intact calves in the first of two e xperiments. In a second experiment, one week later, two daily doses of 20 mg/kg B. W. each of probenecid were orally administered to the sam e animals, from the first to the last day of the experiment. One singl e intravenous application of 60 mg/kg B. W. of sulfamerazine followed on the second day of the experiment. Administration of probenecid had no effect at all on the pharmacokinetics of sulfamerazine, with the la tter not being excreted in a carrier-mediated way by the animals exami ned.