INDUCED PHOTOLYSIS OF RABBIT RED-BLOOD-CELLS BY SEVERAL PHOTOSENSITIZERS

Authors
JUARRANZ A VILLANUEVA A DIAZ V RODRIGUEZBORLADO L TRIGUEROS C CANETE M
Citation
A. Juarranz et al., INDUCED PHOTOLYSIS OF RABBIT RED-BLOOD-CELLS BY SEVERAL PHOTOSENSITIZERS, Anti-cancer drugs, 4(4), 1993, pp. 501-504
Citations number
14
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Anti-cancer drugs → ACNP
ISSN journal
09594973
Volume
4
Issue
4
Year of publication
1993
Pages
501 - 504
Database
ISI
SICI code
0959-4973(1993)4:4<501:IPORRB>2.0.ZU;2-6
Abstract
The photolysis of rabbit red blood cells induced by several photosensi tizers has been studied. Membrane photohemolysis was found to be depen dent on light dose (J/cm2) for hematoporphyrin (HP), methylene blue (M B) and toluidine blue (TB). No significant hemolysis was detected when mesotetra (4N-methylpyridyl) porphine (T4MP(y)P) plus light was used. Sodium azide inhibited, whereas deuterium oxide potentiated membrane lysis with HP, MB and TB. In the case of T4MP(y)P no differences were observed when using sodium azide or deuterium oxide.