Mp. Prasad et M. Kalyanasundaram, IONOTROPIC CROSS-LINKING OF SODIUM CARBOXYMETHYLCELLULOSE AND SODIUM CARBOXYMETHYLCELLULOSE-GELATIN MATRICES AND THEIR EROSION PROPERTIES, Journal of applied polymer science, 49(12), 1993, pp. 2075-2079
Hydrophilic sodium carboxymethylcellulose (NaCMC) matrices were chemic
ally modified into hydrophobic gels by ionotropic crosslinking with cu
pric or ferric ion under ambient temperature and pH. Insoluble matrice
s were also prepared using an interactive polymer gelatin in combinati
on with NaCMC. These matrices underwent erosion at the crosslinks, fol
lowed by matrix erosion when released in water. The matrix erosion in
water was influenced by the gelling agent, initial crosslinker density
, and gelatin content in the insolubilized matrices. The apparent diff
usion coefficients of fenthion ranged from 7.2 X 10(-9) to 175.6 X 10(
-9) cm2/sec, with matrices prepared under different conditions. These
erosion-controlled matrices can be used for the controlled release of
various biologically active agents. (C) 1993 John Wiley & Sons, Inc.