HANDLING PUNCTATE KERATITIS RESULTING FROM SYSTEMIC CYTARABINE

Authors
FRIEDLAND S LOYA N SHAPIRO A
Citation
S. Friedland et al., HANDLING PUNCTATE KERATITIS RESULTING FROM SYSTEMIC CYTARABINE, Annals of ophthalmology, 25(8), 1993, pp. 290-291
Citations number
9
Categorie Soggetti
Ophthalmology
Journal title
Annals of ophthalmology → ACNP
ISSN journal
00034886
Volume
25
Issue
8
Year of publication
1993
Pages
290 - 291
Database
ISI
SICI code
0003-4886(1993)25:8<290:HPKRFS>2.0.ZU;2-R
Abstract
A young patient with acute myelogenous leukemia was treated with high- dose cytarabine (3.0g/m2 every 12 hours). After five days of treatment , he developed severe photophobia and decreased visual acuity. On exam ination, progressive punctate keratitis was found. We discuss the mech anism of the cytarabine-induced corneal toxicity and the prophylactic use of topical corticosteroids.