EFFECTS OF CIPROFLOXACIN AND ENROFLOXACIN ON ZOXAZOLAMINE KINETICS, PLASMA-CONCENTRATION AND SLEEPING TIMES IN MICE

The treatment of CD1 male mice with either ciprofloxacin (CP) or enrof loxacin (EF) prior to zoxazolamine (ZX) administration increased the m ean ZX sleeping times to, respectively, 162 and 156% of the control (Z X alone). At the end of the sleeping time, the mean ZX plasma concentr ation in controls was 27.2 mug/ml and was not different in EF- or CP-t reated groups (87% and 95% of controls, respectively). The animals coa dministered with CP or EF and ZX eliminated the latter more slowly tha n the controls. The estimated zero-time drug concentration of the disp osition curves of both the CP- and EF-treated groups as well as the ap parent half-life of elimination and apparent overall rate of eliminati on of the CP-treated group were different from the control values.