EFFECT OF INTRATRACHEALLY ADMINISTERED LINDANE ON ALDRIN AND BENZO(A)PYRENE CONTENTS IN LUNGS OF RATS

Pretreatment with lindane resulted in inhibition of benzo(a)pyrene hyd roxylase activity in the lungs of rats. The enzyme activity tended to return to normal 5 days after the administration of lindane. Studies w ith benzo(a)pyrene and aldrin indicated reduced elimination of these c ompounds from the lungs of lindane-treated animals, suggesting that li ndane may alter the clearance of certain substances or compounds from lungs. The delayed clearance of these compounds from lungs may be an i ndirect effect of lindane related to inhibition of certain metabolizin g enzymes.