METABOLIC EFFECTS OF DIETARY SUCROSE IN TYPE-II DIABETIC SUBJECTS

OBJECTIVE - To assess in diabetic subjects the effects of dietary sucr ose on glycemia and lipemia. RESEARCH DESIGN AND METHODS- Twelve type II diabetic subjects consumed, in random order, two isocaloric, 55% ca rbohydrate study diets for 28 days. In one diet, 19% of energy was der ived from sucrose. In the other diet, <3% of energy was derived from s ucrose, and carbohydrate energy came primarily from starch. Both study diets were composed of common foods. All meals were prepared in a met abolic kitchen where foods were weighed during meal preparation. RESUL TS - No significant differences were noted between the study diets at any time point in mean plasma glucose. At day 28, mean plasma glucose values for the sucrose diet were 9.6 +/- 0.5 mM and for the starch die t were 9.4 +/- 0.6 mM (P = 0.63). Also, no significant differences wer e observed between the study diets in urine glucose; fasting serum tot al, HDL, or LDL cholesterol; fasting serum TG; or peak postprandial se rum TG. CONClUSIONS - A high sucrose diet did not adversely affect gly cemia or lipemia in type II diabetic subjects.