BIOSYNTHESIS OF DESTRUXINS

Citation
A. Jegorov et al., BIOSYNTHESIS OF DESTRUXINS, Phytochemistry, 33(6), 1993, pp. 1403-1405
Citations number
13
Categorie Soggetti
Plant Sciences
Journal title
ISSN journal
00319422
Volume
33
Issue
6
Year of publication
1993
Pages
1403 - 1405
Database
ISI
SICI code
0031-9422(1993)33:6<1403:BOD>2.0.ZU;2-L
Abstract
L-[Me-C-13]-Methionine, sodium [2-C-13]acetate and sodium [1,2-C-13]ac etate were incorporated into destruxins A, B and E by the entomopathog enic fungus Metarhizium anisopliae. NMR analysis established that meth ionine is involved in the N-methylation Of L-valine and L-alanine, and that one intact acetate unit participates in the biosynthesis of the -CH(OH)-COOH fragment of the hydroxy acid moiety. The presence of two acetate units in proline and isoleucine agrees with the accepted bioch emical schemes.