RUTHENIUM COMPLEX-CATALYZED NOVEL AND FACILE SYNTHESIS OF IMIDAZO[1,2-A]PYRIDINES FROM 2-AMINOPYRIDINES AND VICINAL-DIOLS

Authors
KONDO T KOTACHI S OGINO S WATANABE Y
Citation
T. Kondo et al., RUTHENIUM COMPLEX-CATALYZED NOVEL AND FACILE SYNTHESIS OF IMIDAZO[1,2-A]PYRIDINES FROM 2-AMINOPYRIDINES AND VICINAL-DIOLS, Chemistry Letters, (8), 1993, pp. 1317-1320
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
8
Year of publication
1993
Pages
1317 - 1320
Database
ISI
SICI code
0366-7022(1993):8<1317:RCNAFS>2.0.ZU;2-K
Abstract
Ruthenium complex-catalyzed N-heterocyclization of 2-aminopyridines wi th vicinal-diols offers a novel synthetic method for various imidazo[1 ,2-a]pyridines. For example, the reaction of 2-amino-4-methylpyridine with 1,2-cyclohexanediol in the presence of a catalytic amount of RuCl 2(PPh3)3 under reflux in diglyme for 24 h afforded ethyl-6,7,8,9-tetra hydropyrido[1,2-a]benzimidazole in 74% yield.