VERY EARLY RISK STRATIFICATION BY ELECTROCARDIOGRAM AT REST IN MEN WITH SUSPECTED UNSTABLE CORONARY HEART-DISEASE

Objectives. To determine the possibility of very early prognostic stra tification based on electrocardiograms (ECGs) at rest and/or cardiac e nzyme levels after an episode of suspected unstable coronary heart dis ease. Design and setting. Men with suspected unstable angina or non-Q- wave myocardial infarction were studied in the coronary care units of eight hospitals. The ECGs at rest and creatinine kinase were followed. Subjects. In total 911 men were followed for 12 months. Of 8136 conse cutively admitted, 3365 fulfilled the inclusion criteria. Excluded wer e 2454 patients, mainly because of a larger myocardial damage, signs o f myocardial dysfunction, other serious cardiac or non-cardiac disease or an ECG not possible to interprete regarding ST-T-segment changes i n the precordial leads. Main outcome measures. End-points at follow-up were cardiac death, myocardial infarction and severe (class III or IV ) angina. Results. Compared to patients with normal a ECG who had an 8 % 1 -year risk of myocardial infarction or death, the risk with isolat ed negative T waves was 14% (P < 0.05), ST elevation 16% (P < 0.05), S T depression 18% (P < 0.01) and the combination of ST elevation and ST depression 26% (P < 0.001). The only finding related to future severe angina was ST depression. The risk of cardiac events was comparably e levated in patients with anterior or inferior site of ECG changes. Car diac enzyme levels had no predictive value regarding future events. Co nclusions. Electrocardiograms at rest obtained during the initial days of hospitalization provide very early and valuble prognostic informat ion in men admitted with suspected unstable coronary heart disease.