CONFORMATION OF TROPOLONE RING IN ANTILEUKEMIC TROPOLOISOQUINOLINE ALKALOIDS

Authors
MORITA H MATSUMOTO K TAKEYA K ITOKAWA H
Citation
H. Morita et al., CONFORMATION OF TROPOLONE RING IN ANTILEUKEMIC TROPOLOISOQUINOLINE ALKALOIDS, Chemical and Pharmaceutical Bulletin, 41(8), 1993, pp. 1478-1480
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
8
Year of publication
1993
Pages
1478 - 1480
Database
ISI
SICI code
0009-2363(1993)41:8<1478:COTRIA>2.0.ZU;2-A
Abstract
Conformational analysis of antileukemic tropoloisoquinoline alkaloids isolated from Cissampelos pareira was conducted by thermodynamic proto n nuclear magnetic resonance (H-1 NMR) studies. The line-broadening of one of methoxy methyl signals can be explained by the tropolone ring- puckering process. Analysis by dynamical simulated annealing and modif ied neglect of differential overlap (MNDO) calculations also supported puckering of tropolone ring system.