A CONVENIENT SYNTHESIS OF BENZYLPYRUVIC ACID - THE DOUBLE CARBONYLATION OF PHENETHYL BROMIDE

Authors
MONFLIER E MORTREUX A PETIT F
Citation
E. Monflier et al., A CONVENIENT SYNTHESIS OF BENZYLPYRUVIC ACID - THE DOUBLE CARBONYLATION OF PHENETHYL BROMIDE, Applied catalysis. A, General, 102(1), 1993, pp. 53-67
Citations number
39
Categorie Soggetti
Chemistry Physical","Environmental Sciences
Journal title
Applied catalysis. A, General → ACNP
ISSN journal
0926860X
Volume
102
Issue
1
Year of publication
1993
Pages
53 - 67
Database
ISI
SICI code
0926-860X(1993)102:1<53:ACSOBA>2.0.ZU;2-L
Abstract
Double carbonylation of phenethyl bromide into benzylpyruvic acid in t he presence of a base in hydroalcoholic medium was investigated. The i nfluence of various parameters, such as carbon monoxide pressure, stir ring speed, the nature of the base and the presence of an alkaline iod ide is reported. The role of these last two parameters in the reaction mechanism is discussed. Also, various catalysts were found to catalys e this reaction and the use of cobalt dichloride as a catalyst precurs or may open opportunities for industrial applications.