ANTIHYPERGLYCEMIC ACTIVITY OF NOVEL NAPHTHALENYL 3H-1,2,3,5-OXATHIADIAZOLE 2-OXIDES

A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepar ed and tested for antihyperglycemic activity in the db/db mouse, a mod el for type 2 (non-insulin dependent) diabetes mellitus. Substitution at the 1-, 5-, or 8-positions of the naphthalene ring with a halogen w as found to be beneficial to antihyperglycemic activity. onaphthalen-2 -yl)methyl]-3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most po tent compounds in this series, was selected for further pharmacologica l evaluation.