SYNTHESIS AND ANTIMALARIAL ACTIVITY OF SOME 9-SUBSTITUTED ARTEMISININDERIVATIVES

Authors
ACTON N KARLE JM MILLER RE
Citation
N. Acton et al., SYNTHESIS AND ANTIMALARIAL ACTIVITY OF SOME 9-SUBSTITUTED ARTEMISININDERIVATIVES, Journal of medicinal chemistry, 36(17), 1993, pp. 2552-2557
Citations number
19
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
36
Issue
17
Year of publication
1993
Pages
2552 - 2557
Database
ISI
SICI code
0022-2623(1993)36:17<2552:SAAAOS>2.0.ZU;2-D
Abstract
Several 9-substituted derivatives of the antimalarial drug artemisinin have been prepared by functionalizing the double bond of artemisitene and related compounds. Stereochemical assignments for these compounds were made using a combination of NMR experiments, an X-ray diffractio n study of one compound, and chemical correlations of several other co mpounds with this one compound of unambiguous structure and with its e pimer. The compounds synthesized show a wide variation in in vitro ant imalarial activity.