SPINAL-CORD MOTONEURONS EXPRESS P75(NGFR) AND P145(TRKB) MESSENGER-RNA IN AMYOTROPHIC-LATERAL-SCLEROSIS

Authors
SEEBURGER JL TARRAS S NATTER H SPRINGER JE
Citation
Jl. Seeburger et al., SPINAL-CORD MOTONEURONS EXPRESS P75(NGFR) AND P145(TRKB) MESSENGER-RNA IN AMYOTROPHIC-LATERAL-SCLEROSIS, Brain research, 621(1), 1993, pp. 111-115
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
621
Issue
1
Year of publication
1993
Pages
111 - 115
Database
ISI
SICI code
0006-8993(1993)621:1<111:SMEPAP>2.0.ZU;2-C
Abstract
In the present study, in situ hybridization was used to examine the ex pression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk ) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sect ions. However, p140trk mRNA was not expressed in either ALS or control sections.