THE ROLE OF PHOTOMODIFICATIONS BLOCKED BY THE LIPID-PEROXIDATION INHIBITORS IN THERAPEUTIC ACTION OF UV-IRRADIATED BLOOD ON PERITONITIS IN RATS

Authors
SOKOLOV AY ANOSOV AK ROSHCHUPKIN DJ
Citation
Ay. Sokolov et al., THE ROLE OF PHOTOMODIFICATIONS BLOCKED BY THE LIPID-PEROXIDATION INHIBITORS IN THERAPEUTIC ACTION OF UV-IRRADIATED BLOOD ON PERITONITIS IN RATS, Biofizika, 38(4), 1993, pp. 703-707
Citations number
7
Categorie Soggetti
Biophysics
Journal title
Biofizika → ACNP
ISSN journal
00063029
Volume
38
Issue
4
Year of publication
1993
Pages
703 - 707
Database
ISI
SICI code
0006-3029(1993)38:4<703:TROPBB>2.0.ZU;2-Q
Abstract
The blood of healthy animals was irradiated at 254 nm with incident do se 0.05 Einstein/m2 and was thirdly infused to the rats in volume 2 ml /Kg body weight. The infusion of irradiated blood decreased the lethal ity of rats. Maximal therapeutic action was observed at 7-9th day afte r peritonitis induction. This effect was completely inhibited by injec tion the cyclooxigenase inhibitors aspirin or indomethacin (but not li pid antioxidants BHT or alpha-tocopherol) into irradiated portion of b lood before irradiation. The therapeutic effect of irradiated blood is due to cyclooxigenase activation by UV-radiation.