A COMPARISON OF PEFLOXACIN METRONIDAZOLE AND DOXYCYCLINE METRONIDAZOLE IN THE TREATMENT OF LAPAROSCOPICALLY CONFIRMED ACUTE PELVIC INFLAMMATORY DISEASE

A double-blind, randomised study was conducted to compare the efficacy and safety of a combination of pefloxacin and metronidazole versus do xycycline and metronidazole in patients with pelvic inflammatory disea se (PID). The clinical diagnosis had to be confirmed by laparoscopy be fore patients were included. Of the 74 patients who fulfilled the clin ical criteria for PID, laparoscopy confirmed the diagnosis in only 40 patients (54%). The microorganism most frequently found as causative p athogen was Chlamydia trachomatis. Both treatment groups showed a good response to the study-medication. At discharge 9 patients in the pefl oxacin group (45%) were cured and 10 patients (50%) had improved. In t he doxycycline group 7 patients (35%) were cured and 10 patients (50%) had improved. Obviously pefloxacin/metronidazole and doxycycline/metr onidazole are equally effective in the treatment of PID.