DELETION ANALYSIS OF DUCHENNE MUSCULAR-DYSTROPHY

DNA of 15 patients with Duchenne muscular dystrophy (DMD) were analyze d for deletions within the DMD gene by using recombinant DNA technolog y. Deletion frequency was 47 percent and six of the deletions occurred in the region of probe 7 + 8. Only one of the deletions was observed in the region of probe 9-7, and no deletions were found in the regions of probe 30-1, 30-2 and 47-4 (5b + 6). The frequency of deletions fou nd in the Turkish DMD patients corresponds to frequencies reported for other populations.