ANTIPROLIFERATIVE ACTION OF THE STEROID RU486 IN CULTURED HUMAN LYMPHOMA-CELLS

The antiproliferative properties of the synthetic steroid RU486 on the human lymphoma cell line Daudi are described. In suspension cultures, RU486 (10 muM) caused a time dose and cell density dependent reductio n of cell proliferation. This effect was reversed within 48 h of withd rawal of RU486 from the growth medium. High concentrations of foetal c alf serum can mask the inhibitory effect. In semi-solid cultures RU486 also impaired cell proliferation. Thus RU486 was able to suppress in this tumor cell line the expression of some properties frequently asso ciated with the transformed status of the cells.