ANTIPROMOTING EFFECTS OF 5-LIPOXYGENASE INHIBITORS, 3-NITRO-2,4,6-TRIHYDROXYBENZAMIDE DERIVATIVES, ON TPA-PROMOTED TRANSFORMATION IN BALB 3T3 CELLS

Authors
SEMBA M HONDA I SHIBAGAKI M NISHI Y
Citation
M. Semba et al., ANTIPROMOTING EFFECTS OF 5-LIPOXYGENASE INHIBITORS, 3-NITRO-2,4,6-TRIHYDROXYBENZAMIDE DERIVATIVES, ON TPA-PROMOTED TRANSFORMATION IN BALB 3T3 CELLS, Cancer letters, 71(1-3), 1993, pp. 57-60
Citations number
11
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
71
Issue
1-3
Year of publication
1993
Pages
57 - 60
Database
ISI
SICI code
0304-3835(1993)71:1-3<57:AEO5I3>2.0.ZU;2-U
Abstract
In order to discover the role in the promotion process of 5-lipoxygena se (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB ) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inhibited TPA-promoted transformat ion in a dose-dependent manner. Most of them achieved a 70-80% inhibit ion. Good correlations were observed between the inhibition of TPA-pro moted transformation and that of 5-LO. These results indicate that 5-L O plays an important role in the promotion stage of the transformation of BALB 3T3 cells.