VIRUS-INFECTIONS IN MICE WITH TARGETED GENE DISRUPTIONS

Authors
DOHERTY PC
Citation
Pc. Doherty, VIRUS-INFECTIONS IN MICE WITH TARGETED GENE DISRUPTIONS, Current opinion in immunology, 5(4), 1993, pp. 479-483
Citations number
33
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
5
Issue
4
Year of publication
1993
Pages
479 - 483
Database
ISI
SICI code
0952-7915(1993)5:4<479:VIMWTG>2.0.ZU;2-X
Abstract
The experimental dissection of the ways that the various cells and mol ecules of the immune system interact to promote virus clearance has be en greatly facilitated by the availability of mice with targeted disru ptions of key genes. New insights are emerging, and details of host re sistance mechanisms that could only be inferred for the in vivo situat ion are now being clearly established.