THERMAL-BEHAVIOR AND HEAT-CAPACITY OF SOME HIGH-MOLECULAR-WEIGHT ALCOHOLS AND ESTERS USED IN PHARMACEUTICAL PREPARATIONS

The thermal behaviour and the temperature of evaporation of oleyl alco hol, 2-octyl dodecanol, isopropyl myristate, isopropyl palmitate, oley l oleate, decyl oleate, dibutyl adipate, di(2-ethyl hexyl) adipate and propylene glycol dipelargonate, all of which are frequently used for pharmaceutical purposes, were determined by DSC and TG. All decompose before their boiling points and evaporate at temperatures lower than t his. Therefore, the heat capacity was measured as a function of temper ature in high-pressure crucibles (at constant volume), in the interval between 25-degrees-C and the temperature at which they begin to decom pose.