THE 1ST MOENOMYCIN ANTIBIOTIC WITHOUT THE METHYL-BRANCHED URONIC-ACIDCONSTITUENT - UNEXPECTED STRUCTURE-ACTIVITY RELATIONS

Authors
HESSLERKLINTZ M HOBERT K BIALLASS A SIEGELS T HIEGEMANN M MAULSHAGEN A MULLER D WELZEL P HUBER G BOTTGER D MARKUS A SEIBERT G STARK A FEHLHABER HW VANHEIJENOORT Y VANHEIJENOORT J
Citation
M. Hesslerklintz et al., THE 1ST MOENOMYCIN ANTIBIOTIC WITHOUT THE METHYL-BRANCHED URONIC-ACIDCONSTITUENT - UNEXPECTED STRUCTURE-ACTIVITY RELATIONS, Tetrahedron, 49(35), 1993, pp. 7667-7678
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
35
Year of publication
1993
Pages
7667 - 7678
Database
ISI
SICI code
0040-4020(1993)49:35<7667:T1MAWT>2.0.ZU;2-Y
Abstract
Isolation and structure elucidation of a new moenomycin antibiotic (C1 , 1e) that lacks the branching methyl group in the 4-position of unit F are reported. The smallest antibiotically active degradation product of le is the trisaccharide derivative 3. This observation is in contr ast to structure activity relations in the moenomycin A series where i t was found that disaccharide 4a is fully active.