BIOLOGICAL EVALUATION OF COMPOUNDS WITH -NCS- GROUP OR DERIVED FROM THIAZOLE AND IMIDAZOLE - ACTIVITY ON PROSTAGLANDIN SYNTHETASE COMPLEX

The effects of compounds with activity against thyroid peroxidase were tested on the activity of hydroperoxidase and cyclo-oxygenase of the prostaglandin synthetase complex in-vitro. Active compounds were found to inhibit the peroxidase, and the cyclo-oxygenase function. These co mpounds were also found to have anti-inflammatory activity as demonstr ated by the reduction of carrageenan-induced oedema of the hind paw of the rat. Indomethacin and non-steroidal anti-inflammatory drugs teste d under the same conditions were shown to have activity towards the cy clo-oxygenase rather than the peroxidase function of the prostaglandin synthetase complex. A common feature of the active compounds was the presence of an -NCS- linkage or free -SH group.