K. Uekama et al., PROTECTIVE EFFECTS OF CYCLODEXTRIN SULFATES AGAINST GENTAMICIN-INDUCED NEPHROTOXICITY IN THE RAT, Journal of Pharmacy and Pharmacology, 45(8), 1993, pp. 745-747
The effects of cyclodextrin sulphates on the development of rat renal
dysfunction induced with gentamicin, an aminoglycoside antibiotic, wer
e studied. Daily subcutaneous injection of gentamicin (100 mg kg-1, 14
days) developed nephrotoxicity in the rat as assessed by an increase
in serum urea nitrogen and histopathological changes in the renal cort
ex. When cyclodextrin sulphates were given intraperitoneally at 300 mg
kg-1 at 6 h intervals after gentamicin administration, they protected
the rat against the drug-induced renal impairment, while the parent c
yclodextrins were ineffective. Since post-administration of cyclodextr
in sulphates did not reduce the total amount of gentamicin accumulated
in the kidney, the protection may occur through interference with int
racellular events leading from the drug accumulation to nephrotoxicity
. These results suggest that cyclodextrin sulphates are particularly e
ffective in preventing renal failure associated with aminoglycoside tr
eatment.