EXPERIMENTAL CLOSTRIDIUM-PERFRINGENS TYPE-C INFECTION IN PIGLETS .2. PATHOLOGICAL-STUDY

Pathoanatomical and histopathological studies were carried out in expe rimentally induced Clostridium perfringens type C enterotoxaemia in pi glets. Two types of inoculums were used: whole growing culture inocula ted intragastrically (WGC/IG), and precipitated toxin intraperitoneall y (PT/IP). Grossly, the pronounced changes were noticed in the gastroi ntestinal tract of WGC/IG piglets and consisted of variable congestion , haemorrhages and necrosis mainly extending from mid-jejunum to proxi mal two-thirds of the ileum. The latter was more often severely affect ed than the jejunum. In PT/IP piglets, systemic changes were more pron ounced than the gastrointestinal changes. Only mild congestion was not iced in the small intestine. Other visceral organs also exhibited cong estion and occasional haemorrhage, Important brain lesions were mening eal congestion, perivascular haemorrhage, perivascular cuffing and gli al nodules. The affected cerebellum revealed greater immaturity with d elayed migration of neurogenic cells.