PROTECTIVE EFFECTS OF THE LAZAROID U74500A AND LIDOFLAZINE ON LIVER PRESERVATION WITH UW SOLUTION

The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist , lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model. Following preservation, the livers were rep erfused using a closed circuit, and the release of hepatocellular enzy mes (ASAT, ALAT, and LDH) into the perfusate was determined with incre asing time. Both drugs reduced the amount of enzymes lost from the liv er. The combination of the two drugs was better than either drug alone . These data suggest that both agents may be of value in organ preserv ation for clinical liver transplantation.