CLOSTRIDIUM-DIFFICILE TOXIN-A ELICITS CA2-INDEPENDENT CYTOTOXIC EFFECTS IN CULTURED NORMAL RAT INTESTINAL CRYPT CELLS()

Authors
FIORENTINI C DONELLI G NICOTERA P THELESTAM M
Citation
C. Fiorentini et al., CLOSTRIDIUM-DIFFICILE TOXIN-A ELICITS CA2-INDEPENDENT CYTOTOXIC EFFECTS IN CULTURED NORMAL RAT INTESTINAL CRYPT CELLS(), Infection and immunity, 61(9), 1993, pp. 3988-3993
Citations number
27
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
9
Year of publication
1993
Pages
3988 - 3993
Database
ISI
SICI code
0019-9567(1993)61:9<3988:CTECCE>2.0.ZU;2-2
Abstract
In rat intestinal crypt cells, Clostridium difficile toxin A induces ( i) early cytoskeletal alterations involving the whole population and ( ii) late effects in 30 to 40% of the cells, consisting mainly of surfa ce blebbing and nuclear fragmentation. All these effects were Ca2+ ind ependent and were not abolished by protein synthesis inhibitors.