CONCURRENT HPV-16 INFECTION OF THE NIPPLE AND PERIANAL AREA IN AN HIV-1+ PATIENT

Background In patients with HIV-1 disease there has been an increasing association with human papilloma virus (HPV) infections in multiple l ocations as well as an increase in associated tumors. In addition, the re has been increased recovery Of Hpv in individuals with decreasing T 4 cell counts. Case Report. Recently we have seen an HIV-1+ patient wi th a cutaneous lesion on the nipple, as well as multiple perianal lesi ons in which HPV-16 was demonstrated by in-situ hybridization. Althoug h these lesions contained the same subtype Of HPV virus, they had very different clinical and histopathologic morphologies, and this represe nts the first reported association Of HPV-16 in a nipple lesion. Discu ssion. Our patient illustrates that in HIV-1 disease, HPV infections m ay present in more diffuse and atypical locations. In addition, the di ffuse staining with the in-situ probe for HIV-16 within the lesions, t ends to support the findings of others, that viral recovery increases with the immune suppression induced by HIV-1.