AN EXPERIMENTAL ANTIIDIOTYPE VACCINE MIMICKING LIPOPOLYSACCHARIDE GIVES PROTECTION AGAINST PASTEURELLA-MULTOCIDA TYPE-A INFECTION IN MICE

Authors
SUTHERLAND AD DAVIES RC MURRAY J
Citation
Ad. Sutherland et al., AN EXPERIMENTAL ANTIIDIOTYPE VACCINE MIMICKING LIPOPOLYSACCHARIDE GIVES PROTECTION AGAINST PASTEURELLA-MULTOCIDA TYPE-A INFECTION IN MICE, FEMS immunology and medical microbiology, 7(2), 1993, pp. 105-110
Citations number
21
Categorie Soggetti
Immunology,Microbiology
Journal title
FEMS immunology and medical microbiology → ACNP
ISSN journal
09288244
Volume
7
Issue
2
Year of publication
1993
Pages
105 - 110
Database
ISI
SICI code
0928-8244(1993)7:2<105:AEAVML>2.0.ZU;2-D
Abstract
An anti-idiotype strategy was employed which showed that polyclonal an ti-idiotype antibodies could be produced which could mimic a linear Pa steurella multocida lipopolysaccharide (LPS) molecule. These antibodie s when used as vaccine antigens, induced antibodies which recognised L PS and imparted acquired protection upon syngeneic vaccinates challeng ed with homologous organisms.