PREDICTION OF RESPONSE TO HALOPERIDOL DOSE REDUCTION BY SPAN OF APPREHENSION MEASURES FOR TREATMENT-REFRACTORY SCHIZOPHRENIC-PATIENTS

Thirteen treatment-refractory schizophrenic patients participated in a haloperidol reduction study. Two of the subjects were unable to toler ate medication reduction. These subjects were comparable to the other patients in terms of initial clinical variables but were outliers on b aseline accuracy and reaction time measures from the Span of Apprehens ion. The results suggest that aspects of basic visual processing and m otor response speed may identify patients who require higher neurolept ic doses.