COPPER(II) DIHYDROXYBENZOATES - SYNTHESIS AND PROPERTIES

Compounds of composition Cu(2,5-DHB)2.4H2O (DHB, dihydroxybenzoate ani on) and Cu(2,Y-DHB)2. 8 H2O (Y = 4 or 6) were prepared as potential an tiinflammatory agents with a view of pharmacological screening. The ro om-temperature magnetic moments allow to classify all compounds into t he group of magnetically diluted copper(II) complexes. According to EP R and electronic spectra, the degree of tetragonal distortion increase s passing from Cu(2,6-DHB)2. 8 H2O (III) through Cu(2,4-DHB)2 . 8 H2O (I) to Cu(2,5-DHB)2. 4 H2O (II). The complexes differ also in the coop erative ordering in their structures. All tested compounds exhibit hig her antiinflammatory activities (on dextran edema) than free carboxyli c acids. However, their effects were accompanied with relatively high toxicity. Remarkable results were also achieved on evaluating the anti pyretic activity.