A CONCISE SYNTHESIS OF THE NOVEL ANTIBIOTIC ARANOROSIN

Authors
MCKILLOP A MCLAREN L WATSON RJ TAYLOR RJK LEWIS N
Citation
A. Mckillop et al., A CONCISE SYNTHESIS OF THE NOVEL ANTIBIOTIC ARANOROSIN, Tetrahedron letters, 34(35), 1993, pp. 5519-5522
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
35
Year of publication
1993
Pages
5519 - 5522
Database
ISI
SICI code
0040-4039(1993)34:35<5519:ACSOTN>2.0.ZU;2-9
Abstract
A short synthesis of the novel antibiotic aranorosin is described whic h employs a novel hypervalent iodine-mediated oxidative hydroxylation of a tyrosinal derivative in the key step. A similar procedure was emp loyed to prepare 6'-epiaranorosin, and hence establish the stereochemi stry of the natural compound.