RESOLUTION OF HYDROXYUREAS

Authors
GARIGIPATI RS SORENSON ME ERHARD KF ADAMS JL
Citation
Rs. Garigipati et al., RESOLUTION OF HYDROXYUREAS, Tetrahedron letters, 34(35), 1993, pp. 5537-5540
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
35
Year of publication
1993
Pages
5537 - 5540
Database
ISI
SICI code
0040-4039(1993)34:35<5537:ROH>2.0.ZU;2-5
Abstract
Racemic hydroxyureas can be efficiently resolved on a preparative scal e using (4S)-4-benzyl-2-oxazolidinone-3-carbonyl chloride 3. The resul ting carbamates can be separated by chromatography and hydrolysis of t hese diastereomers yields enantiomerically pure hydroxyureas.