SPECIFIC MONODEUTERATION OF CHALCONES AND RELATED-COMPOUNDS

Authors
SILVA AMS PRICE WA CAVALEIRO JAS
Citation
Ams. Silva et al., SPECIFIC MONODEUTERATION OF CHALCONES AND RELATED-COMPOUNDS, Tetrahedron letters, 34(35), 1993, pp. 5657-5660
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
35
Year of publication
1993
Pages
5657 - 5660
Database
ISI
SICI code
0040-4039(1993)34:35<5657:SMOCAR>2.0.ZU;2-Y
Abstract
The selective deuterations of several chalcones and related flavonoids were carried out with a catalytic amount of KOH in methanol-d1. Produ ct formation showed exclusively alpha-deuteration with the exception o f 2-styryl-chromone, which was completely deuterated at the gamma posi tion. Product formations were verified by H-1 and C-13 NMR spectroscop y and several reactions were monitored by H-1 NMR spectroscopy.