STABILITY OF FLUMAZENIL WITH SELECTED DRUGS IN 5-PERCENT DEXTROSE INJECTION

The compatibility and stability of flumazenil mixed with aminophylline , dobutamine hydrochloride, dopamine hydrochloride, cimetidine hydroch loride, famotidine, ranitidine hydrochloride, heparin sodium, lidocain e hydrochloride, or procainamide hydrochloride were studied. Flumazeni l (1.0 mg) was mixed with each of the other drugs in polyvinyl chlorid e minibags containing 50 mL of 5% dextrose injection to achieve concen trations commonly used when the drugs are administered by continuous i .v. infusion. All admixtures were analyzed for color change, pH, and p articulate matter. Flumazenil concentrations were measured by a stabil ity-indicating high-performance liquid chromatographic assay at baseli ne and 2, 4, 8, 12, and 24 hours after mixing. No detectable changes i n color, pH, or particulate matter were observed. In the presence of e ach drug except dopamine hydrochloride, at least 95% of initial flumaz enil concentration was present 24 hours after mixing. Flumazenil in th e presence of dopamine hydrochloride was stable for 12 hours. Flumazen il was visually compatible and chemically stable when admixed with 5% dextrose injection and selected drugs.