A 3-TIERED VIEW OF THE ROLE OF IGA IN MUCOSAL DEFENSE

Citation
Mb. Mazanec et al., A 3-TIERED VIEW OF THE ROLE OF IGA IN MUCOSAL DEFENSE, Immunology today, 14(9), 1993, pp. 430-435
Citations number
35
Categorie Soggetti
Immunology
Journal title
ISSN journal
01675699
Volume
14
Issue
9
Year of publication
1993
Pages
430 - 435
Database
ISI
SICI code
0167-5699(1993)14:9<430:A3VOTR>2.0.ZU;2-4
Abstract
Mucosal IgA has generally been viewed as an immune barrier to prevent the adherence and absorption of antigens. Recent studies employing pol arized epithelial monolayers have suggested two additional functions f or mucosal IgA. One is to neutralize intracellular microbial pathogens , such as viruses, directly within epithelial cells. The second is to bind antigens in the mucosal lamina propria and excrete them through t he adjacent epithelium into the lumen, thereby ridding the body of loc ally formed immune complexes and decreasing their access to the system ic circulation.