Mg. Palfreyman et al., ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND BEHAVIORAL EVIDENCE FOR 5-HT(2)AND 5-HT(3) MEDIATED CONTROL OF DOPAMINERGIC FUNCTION, Psychopharmacology, 112(1), 1993, pp. 190000060-190000067
Several lines of evidence have suggested a link between serotonergic a
nd dopaminergic systems in the brain. The interpretation of much of th
ese early data needs careful reevaluation in light of the recent under
standing of the plethora of serotonin receptor subtypes, their distrib
ution in the brain and the new findings with more selective serotonin
antagonists. Electrophysiological, biochemical and behavioral evidence
obtained using highly selective antagonists of the 5-HT2 or 5-HT3 rec
eptor subtypes, MDL 100,907 or MDL 73,147EF, respectively, supports th
e thesis that serotonin modulates the dopaminergic system. This modula
tion is most evident when the dopaminergic system has been activated.