A NOVEL HUMAN CDNA WITH A PREDICTED PROTEIN SIMILAR TO LYSYL OXIDASE MAPS TO CHROMOSOME-15Q24-Q25

Authors
KENYON K MODI WS CONTENTE S FRIEDMAN RM
Citation
K. Kenyon et al., A NOVEL HUMAN CDNA WITH A PREDICTED PROTEIN SIMILAR TO LYSYL OXIDASE MAPS TO CHROMOSOME-15Q24-Q25, The Journal of biological chemistry, 268(25), 1993, pp. 18435-18437
Citations number
25
Categorie Soggetti
Biology
Journal title
The Journal of biological chemistry → ACNP
ISSN journal
00219258
Volume
268
Issue
25
Year of publication
1993
Pages
18435 - 18437
Database
ISI
SICI code
0021-9258(1993)268:25<18435:ANHCWA>2.0.ZU;2-9
Abstract
A novel human cDNA with a predicted protein homologous to the carboxyl end of lysyl oxidase, an extracellular enzyme involved in the maturat ion of collagen and elastin, has been isolated. The homology to lysyl oxidase begins exactly at the position of the exon 1/exon 2 boundary i n the mouse gene (Contente, S., Csiszar, K., Kenyon, K., and Friedman, R. M. (1993) Genomics 16, 395-400). This lysyl oxidase-like gene, whi ch appears to be no larger than 22.1 kilobases, codes for a single pol y-adenylated RNA species of 2.48 kilobases and has been mapped to chro mosome 15q24-q25.