INFLUENCE OF ALLOPURINOL ON SKELETAL MUSC ULAR DAMAGE DUE TO ISCHEMIAAND REPERFUSION - P-31 MR SPECTROSCOPY IN-VIVO IN A RAT HINDLEG

Authors
GURKE L MARX A ERHARD P SUTTER PM LANDMANN J HEBERER M
Citation
L. Gurke et al., INFLUENCE OF ALLOPURINOL ON SKELETAL MUSC ULAR DAMAGE DUE TO ISCHEMIAAND REPERFUSION - P-31 MR SPECTROSCOPY IN-VIVO IN A RAT HINDLEG, Helvetica chirurgica acta, 59(5-6), 1993, pp. 877-880
Citations number
NO
Categorie Soggetti
Surgery
Journal title
Helvetica chirurgica acta → ACNP
ISSN journal
00180181
Volume
59
Issue
5-6
Year of publication
1993
Pages
877 - 880
Database
ISI
SICI code
0018-0181(1993)59:5-6<877:IOAOSM>2.0.ZU;2-4
Abstract
The effect of Allopurinol on energy metabolism (reutilisation of hypox anthin) was studied in a in vivo skeletal muscle ischemia rat model by P-31-MR spectroscopy. Allopurinol-treatment showed no benefit to the kinetics of PCr/(Pi + PCr) and ATP/(Pi + PCr). The role of reutilisati on of hypoxantin has to be further investigated.