J. Kovensky et Af. Cirelli, CHEMICAL MODIFICATION OF GLYCOSAMINOGLYCANS - SULFATION OF HEPARAN-SULFATE DERIVATIVES OBTAINED BY PERIODATE-OXIDATION BOROHYDRIDE REDUCTION, Carbohydrate polymers, 31(4), 1996, pp. 211-214
Two heparan sulphates, of different N- and O-sulphate content and idur
onic/ glucuronic acid ratio (HS I and HS II), were submitted to partia
l periodate oxidation, borohydride reduction and subsequent O-sulphati
on. The sulphated derivatives showed increased anticoagulant activitie
s by APTT assay and were significantly degraded by heparinase. (C) 199
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