CHEMICAL MODIFICATION OF GLYCOSAMINOGLYCANS - SULFATION OF HEPARAN-SULFATE DERIVATIVES OBTAINED BY PERIODATE-OXIDATION BOROHYDRIDE REDUCTION

Authors
KOVENSKY J CIRELLI AF
Citation
J. Kovensky et Af. Cirelli, CHEMICAL MODIFICATION OF GLYCOSAMINOGLYCANS - SULFATION OF HEPARAN-SULFATE DERIVATIVES OBTAINED BY PERIODATE-OXIDATION BOROHYDRIDE REDUCTION, Carbohydrate polymers, 31(4), 1996, pp. 211-214
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Polymer Sciences
Journal title
Carbohydrate polymers → ACNP
ISSN journal
01448617
Volume
31
Issue
4
Year of publication
1996
Pages
211 - 214
Database
ISI
SICI code
0144-8617(1996)31:4<211:CMOG-S>2.0.ZU;2-V
Abstract
Two heparan sulphates, of different N- and O-sulphate content and idur onic/ glucuronic acid ratio (HS I and HS II), were submitted to partia l periodate oxidation, borohydride reduction and subsequent O-sulphati on. The sulphated derivatives showed increased anticoagulant activitie s by APTT assay and were significantly degraded by heparinase. (C) 199 7 Published by Elsevier Science Ltd.