ANTITUMOR-ACTIVITY OF ACEMETACIN IN MICE BEARING COLON 26 CARCINOMA -A PRELIMINARY-REPORT

Authors
KISARA S MAEKAWA I SASAKI K SUZUKI N HAYASHI A FURUSAWA S TAKAYANAGI Y SASAKI K
Citation
S. Kisara et al., ANTITUMOR-ACTIVITY OF ACEMETACIN IN MICE BEARING COLON 26 CARCINOMA -A PRELIMINARY-REPORT, Research communications in chemical pathology and pharmacology, 81(2), 1993, pp. 247-250
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in chemical pathology and pharmacology → ACNP
ISSN journal
00345164
Volume
81
Issue
2
Year of publication
1993
Pages
247 - 250
Database
ISI
SICI code
0034-5164(1993)81:2<247:AOAIMB>2.0.ZU;2-D
Abstract
The antitumor activity of acemetacin (ACM) was examined in mice bearin g colon 26 carcinoma and its effect was compared with indomethacin (IN D). The addition of ACM (0.001-0.003 %) to drinking water prolonged th e survival time of mice bearing colon 26. On the other hand, prostagla ndin E2 (PGE2) reduced the effect of ACM. The results suggest that the antitumor activity of ACM may be associated with the reduction of PGE 2 levels.