The clinical course of an adolescent with reflex sympathetic dystrophy
of the foot is presented. The potential problems of establishing obje
ctive diagnostic criteria for reflex sympathetic dystrophy are related
to the dynamic nature of the disorder. Serial radiographic studies, r
adionuclide scans, and quantitative densitometric measurements may be
useful in combination; isolated cold stress testing and laser Doppler
fluxmetry are useful in assessing thermoregulation and vasomotor insta
bility. A regimen of amitriptyline and phenytoin plus physical therapy
with stress loading was useful in this patient, but in many patients
the course is progressive, leading to chronic pain and debilitation.