IN-VIVO AND IN-VITRO STUDIES ON THE EFFECT OF LARVIN AND CYPERMETHRINON ADENOSINE-TRIPHOSPHATASE ACTIVITY OF MALE-RATS

Liver is removed from albino rat and assayed for total adenosine triph osphatase (ATPase) activity following administration with single and r epeated doses of larvin and cypermethrin. The data indicate that the t otal (Na+, K+, Mg2+) dependent ATPase in the liver tissue is significa ntly inhibited by single and repeated doses of both insecticides. This inhibition is more pronounced by the repeated dose of cypermethrin th an that of larvin. The in vitro study revealed that the inhibition enc ountered by different concentration of both larvin and cypermethrin is of the Irreversible non-competitive type. This data indicate that the se insecticides can cause biochemical and histopathological changes in the liver ATPase activity which may inhibit several biochemical funct ions of ATPase system such as: the active transport of metal ions, oxi dative phosphoraltion of liver cells and generally the muscle contrati on.