CONSTITUTION OF THE METABOLIC TYPE OF STREPTOMYCETES DURING THE FIRSTHOURS OF CULTIVATION

Using the examples of biosynthesis of streptomycin, bialaphos, actinor hodin, oligoketides and autoregulators during the first hours of strep tomycete cultivation, it is stressed that the external environment in cooperation with the internal metabolic abilities of the cell determin es the metabolic type that would develop during the life cycle of the producing streptomycetes. If we accept that a certain metabolic type ( from the point of view of the production of secondary metabolites) was determined already during the first hours of cultivation of the micro organisms, we must also admit that the availability of primary metabol ites in the so-called production phase of growth (stationary phase, id iophase, etc.) is to a certain extent determined by the very early sta ges of strain development.